Methods and systems for cell state quantification

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United States of America Patent

PATENT NO 9506167
SERIAL NO

13560527

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Abstract

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Systems, methods, libraries, kits, and computer software tools are provided for designing and producing engineered cells. Such engineered cells can be used for cell state quantification, such as genome, transcriptome and/or proteome quantification. In one aspect, an engineered cell having a plurality of artificially designed oligonucleotides introduced into the genome of the cell is provided. The oligonucleotides are each located in proximity of a gene of interest encoding a protein of interest, and are different from one another. The oligonucleotides can each encode a unique peptide tag for each protein of interest, wherein each peptide tag has a unique quantitatively measurable value such as mass-to-charge ratio which can be quantified by a mass spectrometer. The engineered cell is capable of expressing a plurality of proteins of interest each fused to its corresponding unique peptide tag, wherein each peptide tag is capable of being released therefrom.

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Patent Owner(s)

Patent OwnerAddress
GINKGO BIOWORKS INC27 DRYDOCK AVENUE 8TH FLOOR BOSTON MA 02210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Knight,, Jr Thomas F Belmont, US 14 264
Rettberg, Randall D Concord, US 19 1085
Shetty, Reshma Boston, US 12 129

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