Stable micronised monoclin form of asenapine maleate and its synthesis
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United States of America Patent
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Nov 29, 2016
Grant Date -
May 22, 2014
app pub date -
May 18, 2012
filing date -
May 18, 2011
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Abstract
A stable micronized monoclinic form of asenapine maleate is described, which comprises 5% by weight or less of orthorhombic form or any other crystalline form of asenapine maleate, wherein the asenapine maleate has a particle size distribution characterized by a d90 equal to or below 40 μm. Processes for preparing the stable micronized monoclinic form of asenapine maleate are also described. Formula (I).
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