Process for removing pesticides from ginkgo biloba extracts, and extracts obtainable by said process
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United States of America Patent
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Nov 29, 2016
Grant Date -
Apr 26, 2012
app pub date -
Mar 31, 2010
filing date -
Apr 6, 2009
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Abstract
Process for removing pesticides from Ginkgo biloba extracts, which involves submitting an extract obtained by conventional methods to the following steps:
- a. Liquid-liquid extraction of the extract to obtain a medium polarity fraction containing ginkgo terpenes and pesticides not removable with hexane, and a high polarity fraction containing ginkgo flavone glycosides;b. crystallization from the medium polarity fraction obtained at step a) to give an intermediate with a ginkgolide content of not less than 50%;c. crystallization from the residual solution obtained at step b) to give an intermediate with a bilobalide content of not less than 50%;d. mixing of the high polarity fraction obtained at step a) with the ginkgo terpene intermediate and the bilobalide intermediate obtained at steps b) and c).
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