Cell free DNA diagnostic testing standards
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United States of America Patent
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Nov 22, 2016
Grant Date -
May 28, 2015
app pub date -
Sep 26, 2014
filing date -
Sep 27, 2013
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Abstract
Embodiments of the invention include methods and compositions for producing proficiency testing standards for noninvasive prenatal genetic diagnostics and for the detection and monitoring of cancer. The compositions can include a plurality of different nucleosomal DNA fragments derived from either primary cells or cell lines. The amount of the different nucleosomal DNA fragments can be varied so as to simulate naturally occurring cell free DNA samples obtained from the blood of the pregnant woman or naturally occurring cell free DNA samples obtained from the blood of cancer patients.
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