Selection of triploid CHO cells and cell lines expressing recombinant polypeptides as high producers
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United States of America Patent
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Nov 22, 2016
Grant Date -
Nov 14, 2013
app pub date -
Nov 9, 2011
filing date -
Nov 10, 2010
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Abstract
The present invention relates to a method for selecting for cells or cell lines that produce a recombinant protein/polypeptide in high yields, the method allowing for the selection of high producer cells or cell lines in an early phase of cell line development, the method comprising the step of determining the nuclear DNA content of the cells or cell lines, wherein the level of the nuclear DNA content of the cells or cell lines positively correlates with the capacity of the cells or cell lines to produce the recombinant protein/polypeptide.
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