Multivalent heteromultimer scaffold design and constructs
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United States of America Patent
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Nov 22, 2016
Grant Date -
Sep 27, 2012
app pub date -
Mar 2, 2012
filing date -
Mar 3, 2011
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Abstract
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. These therapeutically novel molecules comprise monomers that function as scaffolds for the conjugation or fusion of therapeutic molecular entities resulting in the creation of bispecific or multivalent molecular species.
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