Truncated L1 protein of human papillomavirus type 52
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United States of America Patent
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Nov 22, 2016
Grant Date -
Sep 5, 2013
app pub date -
Jul 1, 2011
filing date -
Jul 2, 2010
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Abstract
Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at the N-terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein, a virus-like particle (VLP) comprising the protein, and a method of preparing the protein and the VLP using an E. coli expression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and a disease caused by HPV52 infection, such as cervical cancer.
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