Systems and methods for delivery of a therapeutic agent
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United States of America Patent
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Nov 22, 2016
Grant Date -
Jun 4, 2015
app pub date -
Jan 21, 2015
filing date -
Jul 22, 2005
priority date (Note) -
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Abstract
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
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