Determination of in vivo DNA double-strand break localization and application thereof
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United States of America Patent
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Nov 15, 2016
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Jun 6, 2013
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Jan 13, 2011
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Jan 14, 2010
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Abstract
The present invention relates to a method for determining the in vivo localization of double-strand breaks in a host cell, comprising incubating a host cell suspected to comprise DNA double-strand breaks and a linear polynucleotide comprising a known sequence, detecting the in vivo insertion sites of said polynucleotide in the genome of said host cell, and assessing the in vivo localization of double-strand breaks. Further envisaged by the present invention is a method for obtaining an endonuclease with altered in vivo specificity. Finally, the present invention is directed to a kit for determining in vivo specificity of an endonuclease.
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