Bacillus, hyaluronidase, and uses thereof

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United States of America Patent

PATENT NO 9493755
APP PUB NO 20150175991A1
SERIAL NO

14379862

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Abstract

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The present invention provides a bacillus sp. having a deposit access number of CGMCC NO. 5744 and a hyaluronidase produced by the bacillus and the amino acid sequence of the hyaluronidase is shown in SEQ ID NO: 2. The present invention further relates to a process for preparing oligomeric hyaluronic acid or salts thereof or low-molecular-weight hyaluronic acid or salts thereof by using the bacillus or the hyaluronidase produced thereby. The produced oligomeric hyaluronates or low-molecular-weight hyaluronates have advantages such as good transdermal absorption ability, high purity, no cytotoxicity, potent antioxidant ability. The present invention also provides use of the bacillus having a deposit access number of CGMCC NO. 5744, or the hyaluronidase, oligomeric hyaluronates or salts thereof, low-molecular-weight hyaluronates or salts thereof produced by the bacillus in the fields of osmetics, food products and medicines.

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Patent Owner(s)

Patent OwnerAddress
BLOOMAGE BIOTECHNOLOGY CORPORATION LIMITEDNO 678 TIANCHEN STREET HI-TECH DEVELOPMENT ZONE JINAN SHANDONG 250101

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Feng, Ning Jinan, CN 29 1694
Guo, Xueping Jinan, CN 16 12
Li, Haina Jinan, CN 1 2
Liu, Aihua Jinan, CN 21 73
Luan, Yihong Jinan, CN 2 3
Qiao, Liping Jinan, CN 2 2
Shi, Yanli Jinan, CN 3 3
Wang, Guanfeng Jinan, CN 18 135
Wang, Haiying Jinan, CN 49 373
Xue, Wei Jinan, CN 96 665

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