Production of T cell retargeting hetero-dimeric immunoglobulins
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United States of America Patent
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Nov 15, 2016
Grant Date -
May 14, 2015
app pub date -
Nov 4, 2014
filing date -
Nov 4, 2013
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Abstract
The present invention describes novel hetero-dimeric immunoglobulins or fragments thereof which bind to CD3 and a disease associated antigen. These hetero-dimeric immunoglobulins have been engineered to promote hetero-dimer formation during expression and can be purified to a high degree using a Protein A differential purification technique.
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