Peptides associated with HLA-DR MHC class II molecules involved in autoimmune diseases
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United States of America Patent
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Nov 15, 2016
Grant Date -
Dec 20, 2007
app pub date -
Mar 5, 2004
filing date -
Mar 7, 2003
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Abstract
Antigenic peptides that bind to MHC Class II molecules with the shared epitope referred to as HLA-DR molecules are disclosed. More specifically, are citrullinated antigenic peptides having an increased affinity for HLA-DR molecules and associated with Rheumatoid arthritis. These novel peptides provide the basis for new methods of diagnosis and treatment of Rheumatoid arthritis.
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