3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
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United States of America Patent
Stats
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Nov 15, 2016
Grant Date -
Jun 21, 2012
app pub date -
Jul 16, 2010
filing date -
Jul 17, 2009
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (I) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
First Claim
all claims..Other Claims data not available
Family
Country | kind | publication No. | Filing Date | Type | Sub-Type |
---|---|---|---|---|---|
WO | A1 | WO2011008110 | Jul 16, 2010 | Patent | Application |
Type : Patent Sub-Type : Application | |||||
INTERNATIONAL APPLICATION PUBLISHED WITH INTERNATIONAL SEARCH REPORT | 3-HYDROXYPYRROLIDINE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE | Jan 20, 2011 | |||
EP | B1 | EP2454263 | Jul 16, 2010 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
Patent | 3-HYDROXYPYRROLIDINE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE | Jun 13, 2018 | |||
JP | B2 | JP5861243 | Jul 16, 2010 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
PUBLISHED GRANTED PATENT (SECOND LEVEL) | 5’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの3−ヒドロキシピロリジン阻害剤 | Feb 16, 2016 | |||
CA | C | CA2768291 | Jul 16, 2010 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
PATENT (SECOND LEVEL) | 3-HYDROXYPYRROLIDINE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE | Mar 27, 2018 | |||
AU | B2 | AU2010271532 | Jul 16, 2010 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
PATENT PROCEEDED BY OPI | 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase | Mar 03, 2016 | |||
US | B2 | US9957272 | Nov 10, 2016 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
GRANTED PATENT AS SECOND PUBLICATION | 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase | May 01, 2018 |
- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
ALBERT EINSTEIN COLLEGE OF MEDICINE | 1300 MORRIS PARK AVENUE BRONX NY 10461 |
International Classification(s)

- 2010 Application Filing Year
- A61K Class
- 10962 Applications Filed
- 7633 Patents Issued To-Date
- 69.64 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Evans, Gary Brian | Normandale, NZ | 23 | 256 |
# of filed Patents : 23 Total Citations : 256 | |||
Longshaw, Alistair Ian | Thorndon, NZ | 21 | 301 |
# of filed Patents : 21 Total Citations : 301 | |||
Schramm, Vern L | New Rochelle, US | 63 | 758 |
# of filed Patents : 63 Total Citations : 758 | |||
Tyler, Peter Charles | Northland, NZ | 44 | 620 |
# of filed Patents : 44 Total Citations : 620 |
Cited Art Landscape
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Patent Citation Ranking
- 3 Citation Count
- A61K Class
- 38.16 % this patent is cited more than
- 9 Age
Forward Cite Landscape
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | May 15, 2028 |
Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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Apr 03, 2003 | STCF | INFORMATION ON STATUS: PATENT GRANT | free format text: PATENTED CASE |
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Sep 10, 2001 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GITSEVICH, ALEKSANDR;KIRKPATRICK, DOUGLAS A.;MACLENNAN, DONALD A.;REEL/FRAME:012087/0801 Owner name: FUSION LIGHTING, INC., MARYLAND Effective Date: Sep 10, 2001 |
Sep 12, 2000 | PD | Priority Date |

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