3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase

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United States of America Patent

PATENT NO 9493465
APP PUB NO 20120157479A1
SERIAL NO

13383772

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Abstract

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The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (I) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.

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ALBERT EINSTEIN COLLEGE OF MEDICINE1300 MORRIS PARK AVENUE BRONX NY 10461

International Classification(s)

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  • 2010 Application Filing Year
  • A61K Class
  • 10962 Applications Filed
  • 7633 Patents Issued To-Date
  • 69.64 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2010201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Evans, Gary Brian Normandale, NZ 23 256
Longshaw, Alistair Ian Thorndon, NZ 21 301
Schramm, Vern L New Rochelle, US 63 758
Tyler, Peter Charles Northland, NZ 44 620

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  • 3 Citation Count
  • A61K Class
  • 38.16 % this patent is cited more than
  • 9 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges6209860894426710349291291182201 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0500100015002000250030003500400045005000550060006500700075008000850090009500

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