Dimeric binding proteins based on modified ubiquitins
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United States of America Patent
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Nov 15, 2016
Grant Date -
May 8, 2014
app pub date -
Jun 15, 2012
filing date -
Jun 15, 2011
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Abstract
The present invention refers to novel dimeric proteins obtained from modified ubiquitin capable of binding targets with high affinity. The novel dimeric binding proteins comprise a combination of amino acid substitutions and at least one insertion of amino acids in one of the monomers. The invention is further directed to the use of said proteins in medical diagnosis or treatment methods.
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