Influenza virus-like particles (VLPS) comprising hemagglutinin
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United States of America Patent
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Nov 15, 2016
Grant Date -
Dec 1, 2011
app pub date -
Jul 2, 2009
filing date -
Jul 13, 2007
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Abstract
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein of type A/California/04/09 and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA of type A/California/04/09 as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
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