Detecting and treating dementia

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United States of America Patent

PATENT NO 9486541
APP PUB NO 20130345142A1
SERIAL NO

13932727

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Abstract

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This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

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Patent Owner(s)

  • MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;UNIVERSITEIT ANTWERPEN;THE UNIVERSITY OF BRITISH COLUMBIA;THE UNIVERSITY OF MANCHESTER;VIB VZW;UNIVERSTEIT ANTWERPEN

International Classification(s)

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  • 2013 Application Filing Year
  • A61K Class
  • 12711 Applications Filed
  • 11051 Patents Issued To-Date
  • 86.95 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baker, Matthew Charles Jacksonville, US 2 22
Broeckhoven, Christine Van Edegem, BE 5 41
Cannon, Ashley Diane Jacksonville, US 2 22
Cruts, Marc Antwerpen, BE 2 46
Eriksen, Jason Houston, US 9 52
Feldman, Howard Vancouver, CA 7 91
Gass, Jennifer Mae Atlantic Beach, US 2 46
Hutton, Michael L Newton, US 4 56
Kumar-Singh, Samir Edegem, BE 2 46
Mackenzie, Ian Reid Alexander Vancouver, CA 2 46
Pickering-Brown, Stuart M Derbyshire, GB 2 46
Rademakers, Rosa Ponte Vedra, US 4 59

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Patent Citation Ranking

  • 11 Citation Count
  • A61K Class
  • 91.06 % this patent is cited more than
  • 9 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges6209860894426710349291291182201 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0500100015002000250030003500400045005000550060006500700075008000850090009500

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11.5 Year Payment $7400.00 $3700.00 $1850.00 May 8, 2028