Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof
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United States of America Patent
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Nov 1, 2016
Grant Date -
Jan 10, 2013
app pub date -
Jan 19, 2011
filing date -
Jan 19, 2010
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Abstract
An NSAID formulation for encapsulation into a soft gel capsule with increased stability, concentration and bioavailability of the NSAID. The preferred NSAIDS are naproxen, ibprofen, indomethacin and diclofenac, which are provided in both an acidic and basic form in the fill formulation. The pH values of fill formulations may be adjusted without additional process steps. A process for increasing the achievable concentration of an NASAID pharmaceutical ingredient in a fill composition for dosage units is also provided. The highly concentrated NASAID formulation permits a reduction in the fill volume or dosage unit size or an increase in concentration of the NSAID in each dosage it.
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