Low-temperature synthesis of methylphenidate hydrochloride

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United States of America Patent

PATENT NO 9475770
APP PUB NO 20150038720A1
SERIAL NO

13994393

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Abstract

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The present invention describes a process for the preparation of methylphenidate hydrochloride. The process involves the esterification of ritalinic acid and methanol in the presence of an acid catalyst at a low temperature. The process may optionally involve the addition of an orthoester.

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Patent Owner(s)

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NORAMCO LLC500 SWEDES LANDING ROAD WILMINGTON DE 19801

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huntley, C Frederick M East Greenwich, US 10 13
Kataisto, Erik Wayne West Warwick, US 7 13
La, Lumiere Knicholaus Dudley Groton, US 1 1
Reisch, Helge Alfred Westerly, US 24 56

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