Methods for the reactivation of latent HIV using cytosine methylation inhibitors and NF-KB activators
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United States of America Patent
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Oct 25, 2016
Grant Date -
Dec 15, 2011
app pub date -
Apr 15, 2011
filing date -
May 10, 2010
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Abstract
The present disclosure provides methods and compositions for reactivating latent immunodeficiency virus in an immunodeficiency virus-infected cell. The methods generally involve contacting an immunodeficiency virus-infected cell with a synergistically effective amount of an inhibitor of cytosine methylation and an NF-κB activator. The present disclosure provides methods and compositions for reducing the reservoir of latent immunodeficiency virus in an individual, and for treating an immunodeficiency virus infection in an individual.
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