Compositions and methods for amelioration and prevention of drug-induced toxicity

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United States of America Patent

PATENT NO 9474763
APP PUB NO 20150080348A1
SERIAL NO

14551724

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Abstract

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Pharmaceutical compositions including combinations of protective agents selected from isosilybin B, methylsulfonylmethane (MSM), phosphatidylcholine, cysteine (Cys), seleno-cysteine (Se-Cys), ribose-cysteine (RibCys), N-acetylcysteine (NAC), N-acetylcysteine-amide (AD4), methionine (Met) and S-adenosylmethionine (SAM) for reducing and/or preventing drug-induced toxicity, such as acetaminophen-induced toxicity. The compositions may be formulated with or without acetaminophen, and accordingly may be used as safe formulations of acetaminophen with reduced risk of causing liver damage, or as an antidote for the treatment of acetaminophen overdose. Methods for treating acetaminophen intoxication.

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Patent Owner(s)

Patent OwnerAddress
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTDJERUSALEM BIOPARK HADASSAH EIN KEREM MEDICAL CENTER JERUSALEM 9112001

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ilan, Yaron Jerusalem, IL 103 375
Mograbi, Josef Tel Aviv, IL 9 52

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