Biosensor for detecting RAF/KSR family kinase dimerization and uses thereof
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United States of America Patent
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Oct 11, 2016
Grant Date -
Dec 25, 2014
app pub date -
Dec 20, 2013
filing date -
Jul 24, 2009
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Abstract
Disclosed herein are biosensors useful for detecting the dimerization of RAF and/or KSR polypeptides. These biosensors comprise fusion proteins comprising RAF and/or KSR proteins fused to bioluminescent or fluorescent proteins. Also disclosed are methods of using the biosensors to detect and measure the dimerization of RAF/RAF and RAF/KSR polypeptides by resonance energy transfer such as BRET or FRET, for example to screen for inhibitors of dimerization.
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