Sense oligonucleotide capable of controlling the expression of INOS and composition comprising the same

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United States of America Patent

PATENT NO 9464292
APP PUB NO 20150191733A1
SERIAL NO

14568459

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Abstract

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The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.

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Patent Owner(s)

Patent OwnerAddress
AMINO UP CO LTD363-32 SHIN-EI KIYOTA-KU SAPPORO-SHI

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kamiyama, Yasuo Osaka, JP 22 160
Miura, Takehito Sapporo, JP 10 65
Nishizawa, Mikio Osaka, JP 6 23
Okumura, Tadayoshi Osaka, JP 4 16
Wakame, Koji Sapporo, JP 6 16

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