Importance

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Abstract

The invention relates to peptides of general formula (I):

description='In-line Formulae' end='lead'R₁-AA-R₂  (I)description='In-line Formulae' end='tail'

which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R₁ is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R₂ is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R₁ is H or acetyl, R₂ is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.

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First Claim