Anti-BAFFR antibody formulations
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United States of America Patent
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Oct 4, 2016
Grant Date -
Jul 3, 2014
app pub date -
Dec 8, 2011
filing date -
Dec 10, 2010
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Abstract
Anti-BAFFR antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration of the antibody active ingredient for delivery to a patient without high levels of antibody aggregation. The lyophilisate can be reconstituted with an aqueous reconstituent to provide an aqueous composition in which the antibody has a concentration of at least 50 mg/ml. The lyophilisate or aqueous pharmaceutical composition may include one or more of a sugar, a buffering agent, a surfactant, and/or a free amino acid.
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