Crystal form of dabrafenib and preparation method and use thereof
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United States of America Patent
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Oct 4, 2016
Grant Date -
Jul 21, 2016
app pub date -
Mar 25, 2016
filing date -
Apr 17, 2013
priority date (Note) -
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Abstract
The invention relates to Crystal Form VII of dabrafenib and preparation method thereof, wherein Crystal Form VII has the advantage of being more stable at room temperature or in aqueous systems, and has low hygroscopicity, and thus is more suitable for a wet granulation process or being prepared into a suspension; and the present invention also relates to a pharmaceutical composition and formulations comprising Crystal Form VII, and their use in the treatment of Raf family kinase-related diseases.
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