Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery

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United States of America Patent

PATENT NO 9457096
APP PUB NO 20140011739A1
SERIAL NO

13843766

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Abstract

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The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.

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Patent Owner(s)

Patent OwnerAddress
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET)BUENOS AIRES C1033 AAJ
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)4 PLACE JUSSIEU PARIS 75005
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS3 AVENUE VICTORIA PARIS F-75004
UNIVERSIDAD CATOLICA DE CORDOBACALLE OBISPO TREJO 323 CORDOBA 5000

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Klatzmann, David Paris, FR 48 550
Lujan, Hugo Cordoba, AR 4 9
Piaggio, Eliane Paris, FR 22 85

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