Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response

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United States of America Patent

PATENT NO 9453228
SERIAL NO

14955418

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Abstract

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The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

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Patent Owner(s)

Patent OwnerAddress
IDERA PHARMACEUTICALS INCCAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agrawal, Sudhir Shrewsbury, US 223 8509
Bhagat, Lakshmi Framingham, US 54 1124
Kandimalla, Ekambar R Southboro, US 70 1668
Li, Yukui Newton, US 15 412
Wang, Daqing Bedford, US 91 766
Yu, Dong Westboro, US 354 6818
Zhu, FuGang Bedford, US 11 199

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