Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
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United States of America Patent
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Sep 27, 2016
Grant Date -
Jun 12, 2014
app pub date -
Jun 8, 2012
filing date -
Jun 10, 2011
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Abstract
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
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