Method of synthesizing peptides, proteins and bioconjugates
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United States of America Patent
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Sep 27, 2016
Grant Date -
Dec 3, 2015
app pub date -
Feb 6, 2013
filing date -
Feb 7, 2012
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Abstract
The invention relates to the synthesis of peptides, proteins and related bioconjugates, and in particular, to such synthesis using a peptide ligation method whereby a C-terminal salicylaldehyde ester peptide is reacted with an aminoacyl-N-hydroxl peptide. The invention also relates to the synthesis of cyclic peptides, including serinyl- or threonyl-containing cyclic peptides. The invention further relates to a solid phase synthesis of C-terminal salicylaldehyde ester peptides.
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