Glycodendrimers of polypropyletherimine
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United States of America Patent
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Sep 27, 2016
Grant Date -
May 7, 2015
app pub date -
Aug 22, 2011
filing date -
Aug 24, 2010
priority date (Note) -
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Abstract
A glycodendrimer comprising: a) a non-toxic dendrimer polypropyletherimine core supporting on average in the range of 9 to 64 terminal carboxylic acid groups, and b) conjugated to said core in the range of 2 to 8 amino sugars or a sulphate amino sugar selected from the group consisting of glucosamine, N-acetyl glucosamine, mannosamine, N-acetylmannosamine, galactosamine, a sulphate of any one of the same and a combination thereof, wherein each sugar is linked directly through a zero length amide bond with a residue of a terminal carboxylic acid group. The invention also extends to defined populations comprising said glycodendrimer molecules, pharmaceutical compositions comprising said molecules or populations, process for preparing the molecules and formulations, and therapeutic uses of the molecules, populations and compositions.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- A01N:PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLA....
- C07G:COMPOUNDS OF UNKNOWN CONSTITUTION
- C08G:MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN B....
- C08B:POLYSACCHARIDES; DERIVATIVES THEREOF
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