Method and apparatus for testing cardiotoxicity and evaluating cardiomyocytes
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United States of America Patent
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Sep 20, 2016
Grant Date -
Sep 5, 2013
app pub date -
Sep 30, 2011
filing date -
Sep 30, 2010
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Abstract
In the present invention, a cardiomyocyte cluster is disposed on a transparent substrate, and the quality of the cardiomyocytes is evaluated from the response of the cells to a forced pulsation stimulus applied to the cardiomyocytes. The cardiomyocyte cluster is disposed on the transparent substrate, and is exposed to the flow of a liquid containing an agent in a manner so that the agent acts on the cells, which configure a network. The extent of cardiac toxicity resulting from the agent is evaluated from measuring the fluctuations obtained from a comparison of adjacent cardiomyocytes of the network.
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