Pro- and anti-angiogenic treatments
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United States of America Patent
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Sep 20, 2016
Grant Date -
Aug 19, 2010
app pub date -
Mar 10, 2008
filing date -
Mar 9, 2007
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Abstract
The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favors proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favors distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.
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