Generation of induced pluripotent stem cells from small volumes of peripheral blood
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United States of America Patent
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Sep 20, 2016
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Feb 12, 2014
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Jun 15, 2010
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Abstract
Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
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