Methods for suppressing cancer by inhibition of TMCC3
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United States of America Patent
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Sep 20, 2016
Grant Date -
Dec 11, 2014
app pub date -
Mar 24, 2014
filing date -
Mar 24, 2013
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Abstract
A method for treating cancer includes administering to a subject in need thereof an antibody against a transmembrane and coiled-coil domains protein 3 (TMCC3), wherein the antibody binds to an epitope in an extracellular domain of TMCC3. The antibody binds to an epitope in an intercoil domain of TMCC3. A method of diagnosing or assessing a cancer condition includes assessing a level of expression or activity of a transmembrane and coiled-coil domains protein 3 (TMCC3) in a sample, wherein an increase in the level of expression of activity of TMCC3 as compared to a standard indicates the presence of cancer stem cells in the sample.
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