Deuterated morphine derivatives
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United States of America Patent
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Sep 20, 2016
Grant Date -
Feb 25, 2016
app pub date -
Apr 14, 2014
filing date -
Apr 15, 2013
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Abstract
The invention relates to new morphine derivatives deuterated at the 7,8-position of the morphine ring, furthermore to a process for the preparation thereof, and to pharmaceutical compositions comprising them. The new deuterated morphine derivatives show high and selective μ-opioid receptor binding activity leading to the benefit of higher analgesic activity at lower dosages inducing thereby reduced adverse effects compared to the hydrogenated derivatives. The compounds of the invention are useful for example in the treatment of pain or can be used as antitussive agents with a reduced risk of the possibility of drug abuse.
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