Therapeutic aryl-amido-aryl compounds and their use

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United States of America Patent

PATENT NO 9447028
APP PUB NO 20160039747A1
SERIAL NO

14879340

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Abstract

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The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as “AAA compounds”), which, inter alia, are (selective) retinoic acid receptor α (RARα) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARα, and in the treatment of diseases and conditions that are mediated by RARα, that are ameliorated by the activation of RARα, etc., including cognitive disorders, memory impairment, memory deficit, senile dementia, Alzheimer's disease, early stage Alzheimer's disease, intermediate stage Alzheimer's disease, late stage Alzheimer's disease, cognitive impairment, and mild cognitive impairment.

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Patent Owner(s)

Patent OwnerAddress
KING'S COLLEGE LONDONSTRAND LONDON WC2R 2LS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adams, David Reginald High Wycombe, GB 29 95
Borthwick, Alan David London, GB 29 105
Brown, Jane Theresa Nottingham, GB 8 19
Corcoran, Jonathan Patrick Thomas London, GB 12 34
Kalindjian, Sarkis Barret London, GB 25 184
Shiers, Jason John Nottingham, GB 13 3
Taddei, David Michel Adrien Nottingham, GB 16 195

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