KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
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United States of America Patent
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Sep 20, 2016
Grant Date -
Sep 25, 2014
app pub date -
Dec 17, 2013
filing date -
Mar 1, 2002
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Abstract
The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 μM), and dimer and multimeric constructs comprising these polypeptides.
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