Diether based biodegradable cationic lipids for siRNA delivery
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United States of America Patent
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Sep 20, 2016
Grant Date -
Feb 26, 2015
app pub date -
Mar 25, 2013
filing date -
Mar 27, 2012
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Abstract
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. The cationic lipids can demonstrate enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.
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