Method for increasing the intraocular pressure in an animal
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United States of America Patent
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Sep 13, 2016
Grant Date -
Jun 26, 2014
app pub date -
Jul 27, 2012
filing date -
Jul 29, 2011
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Abstract
The present invention concerns a method for inducing an increase in the intraocular pressure in an animal, said method comprising ocular administration of a solution comprising benzalkonium chloride (BAK). The present invention further relates to an animal having ocular hypertension, said animal being obtained by the method according to the invention. Said animal provides a convenient animal model for better understanding of the patho-physiological mechanisms involved in ocular hypertension and glaucoma. The present invention also relates to the use of said animal for screening a compound for therapeutic use against ocular hypertension or glaucoma, and/or for assessing potential side-effects of treatment of ocular hypertension and glaucoma.
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