Macrocyclic cysteine protease inhibitors and compositions thereof
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United States of America Patent
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Sep 6, 2016
Grant Date -
Jul 10, 2014
app pub date -
Mar 12, 2014
filing date -
Oct 18, 2006
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Abstract
The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.
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