Process for producing optically active succinimide derivatives and intermediates thereof
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United States of America Patent
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Sep 6, 2016
Grant Date -
Apr 10, 2014
app pub date -
Dec 12, 2013
filing date -
Feb 6, 2009
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Abstract
Provided is a process for producing (3R)-2′-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine}-1′,2,3′,5(2′H)-tetraone (compound A). The method includes converting an optically active succinimide derivative of formula (I) to compound A, in which the compound of formula (I) has been prepared by reacting a base with an optically active amide derivative of formula (VI).
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