Method for preparing linezolid intermediate

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United States of America Patent

PATENT NO 9434702
APP PUB NO 20150011757A1
SERIAL NO

14378825

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Abstract

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Disclosed is a new method for preparing a methyl substitute of a linezolid intermediate, (S)-2-(3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazoline) (I), wherein the intermediate (I) is obtained by the cyclization of 3-fluoro-4-morpholinophenyl isocyanate (II) and epoxy compound (III). This process has a short process route, low cost, easy operation, and high yield, so is suitable for a large-scale industrial production.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG HISUN PHARMACEUTICAL CO LTDJIAOJIANG DISTRICT OF TAIZHOU CITY ZHEJIANG PROVINCE 318000 ROAD OUTSIDE NO 46 TAIZHOU CITY ZHEJIANG PROVINCE 318000
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY200040 NO 1320 WEST BEIJING ROAD SHANGHAI SHANGHAI CITY SHANGHAI CITY 200040

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cai, Qingfeng Zhejiang, CN 5 10
Chai, Jian Zhejiang, CN 9 1
Li, Jiang Zhejiang, CN 294 4548
Liang, Bin Shangai, CN 102 156
Luo, Hairong Zhejiang, CN 3 8
Qiu, Pengcheng Shangai, CN 4 1
Yang, Chunbo Shangai, CN 8 17
Zhang, Fuli Shangai, CN 12 4

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