Compositions and methods for silencing apolipoprotein C-III expression
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United States of America Patent
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Aug 30, 2016
Grant Date -
Nov 5, 2015
app pub date -
Apr 1, 2015
filing date -
Jan 26, 2009
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Abstract
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for the treatment of lipid diseases or disorders such as atherosclerosis or a dyslipidemia such as hypertriglyceridemia or hypercholesterolemia).
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