Differentiation of pluripotent stem cells with a kinase inhibitor or PGI2

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United States of America Patent

PATENT NO 9422521
SERIAL NO

12066624

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Abstract

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The present invention provides a process of differentiating stem cells, in particular hES cells, into cardiomyocytes and into neural progenitors by growing the hES cells in the presence of a defined medium that is substantially free of xeno- and serum-components and thus comprises a clinically compliant medium. The defined media comprises defined factors that contribute to the promotion of differentiation to cardiomyocytes and neural progenitors. The invention also includes defined culture media and cell populations and methods of using them.

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Patent Owner(s)

Patent OwnerAddress
ES CELL INTERNATIONAL PTE LTD60 BIOPOLIS STREET #01-03 GENOME SINGAPORE 138672

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davidson, Bruce Paul Singapore, SG 5 37
Graichen, Ralph Eberard Singapore, SG 1 0
Xu, Xiuqin Singapore, SG 3 23
Zweigerdt, Robert Singapore, SG 8 29

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