Stable and soluble antibodies inhibiting TNF alpha
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United States of America Patent
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Aug 23, 2016
Grant Date -
Jul 10, 2014
app pub date -
Dec 19, 2013
filing date -
Jun 25, 2008
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Abstract
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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