Vaccine
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United States of America Patent
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Aug 23, 2016
Grant Date -
Oct 9, 2014
app pub date -
Oct 24, 2012
filing date -
Oct 25, 2011
priority date (Note) -
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Abstract
There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.
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