Modified toll-like receptor 2 (TLR2) ligands as inhibitors of neutrophil recruitment
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United States of America Patent
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Aug 23, 2016
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Mar 5, 2015
app pub date -
Aug 30, 2012
filing date -
Aug 30, 2011
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Abstract
The present invention provides modified TLR2 ligands useful for modulating inflammatory responses. In particular, the ligands comprise (a) a fatty acid di- or tri-linoleate and (b) a GM1-binding peptide. The linoleate provides the anti-inflammatory function, while the GM1-binding peptide facilitates endocytosis.
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