Saponin nano micelle, preparing method, application and pharmaceutical composition thereof

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United States of America Patent

PATENT NO 9421269
APP PUB NO 20150297727A1
SERIAL NO

14370885

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Abstract

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A saponin nano micelle, preparing method, application and pharmaceutical composition thereof is disclosed in the present invention. The saponin nano micelle comprises one or more of saponins represented by formula 1, in which, R1 and R2 are independently —H or a hydrophilic group, R3 is —H or —OH, R4 is a lipophilic group. The preparing method of the saponin nano micelle is that mixing the saponin with an organic solvent which can dissolve saponin, and then removing the organic solvent. The saponin micelle acts as a convey medium of the drug ingredients, and can replace conventional drug carriers such as pharmaceutical solubilizers or polymeric micelle, which has high safety and great significance. The pharmaceutical ingredients can prolong circulation time and biological half-life of drug in the blood, and increase the accumulation of drug in lesions, and reduce adverse reactions.

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Patent Owner(s)

Patent OwnerAddress
FUJIAN SOUTH PHARMACEUTICAL CO LTDNO 98 DONGXIN ROAD XUEFENG TOWN MINGXI COUNTY SANMING CITY FUJIAN PROVINCE CHINA 365299 SANMING CITY FUJIAN PROVINCE 365299

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Du, Min Fujian, CN 26 48
Jiang, Zhihong Macao, CN 18 26
Luo, Jianping Fujian, CN 6 7
Miao, Pengfei Shanghai, CN 1 0
Shen, Xin Shanghai, CN 38 2603
Wang, Dan Shanghai, CN 314 948
Yang, Jidong Shanghai, CN 33 271
Zhan, Huaxing Shanghai, CN 6 8
Zhang, Hongsheng Yunnan, CN 18 112

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