Diagnosis of bacterial meningitis based on the measure of ROS production in a sample of cerebrospinal fluid
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United States of America Patent
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Aug 16, 2016
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Jun 20, 2013
app pub date -
Jul 26, 2011
filing date -
Jul 26, 2010
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Abstract
The present invention pertains to a method for in vitro diagnosing a bacterial infection in a biological fluid selected amongst cerebrospinal fluid, ascitic fluid, pericardial fluid, pleural fluid, urine and synovial fluid, based on the measure, in a sample of said fluid, of the production of reactive oxygen species (ROS); a high level of ROS production is indicative of the presence of activated polymorphonuclear neutrophils (PMNs) in said fluid, which in turn is a hallmark of bacterial infection.
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