Humanized monoclonal antibodies and methods of use

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United States of America Patent

PATENT NO 9416169
APP PUB NO 20160176985A1
SERIAL NO

14597044

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Abstract

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The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes the same epitope. Binding of the invented antibody to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.

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Patent Owner(s)

Patent OwnerAddress
THE BRIGHAM AND WOMEN'S HOSPITAL75 FRANCIS STREET BOSTON MA 02115

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kupper, Thomas Belmont, US 19 861
Marasco, Wayne Wellesley, US 12 70
Sui, Jianhua Waltham, US 33 151
Zhu, Quan Needham, US 39 89

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